Table 5 Causal mediation analysis of KDM-BAacc on associations of obesity with incident CVD

Stroke

BMI

1.28 (1.16–1.42)

1.25 (1.12–1.39)

1.03 (1.01–1.05)

WC

1.32 (1.15–1.51)

1.27 (1.1–1.46)

1.04 (1.02–1.06)

WtHR

1.37 (1.19–1.57)

1.32 (1.14–1.52)

1.04 (1.01–1.06)

BRI

1.33 (1.18–1.49)

1.28 (1.14–1.45)

1.03 (1.01–1.06)

CVAI

1.43 (1.22–1.66)

1.37 (1.17–1.60)

1.04 (1.02–1.07)

LAP

1.15 (1.04–1.28)

1.11 (1.00–1.24)

1.03 (1.01–1.05)

TyG

1.25 (1.05–1.49)

1.19 (1.00–1.42)

1.05 (1.02–1.08)

TyG-BMI

1.37 (1.22–1.55)

1.32 (1.16–1.49)

1.04 (1.02–1.07)

TyG-WC

1.41 (1.21–1.65)

1.34 (1.14–1.57)

1.06 (1.02–1.09)

TyG-WtHR

1.48 (1.26–1.74)

1.40 (1.18–1.66)

1.06 (1.02–1.09)

Heart disease

BMI

1.17 (1.07–1.29)

1.15 (1.05–1.27)

1.02 (1.00–1.03)

WC

1.23 (1.10–1.37)

1.20 (1.07–1.35)

1.02 (1.01–1.04)

WtHR

1.19 (1.06–1.33)

1.16 (1.03–1.30)

1.02 (1.01–1.04)

BRI

1.19 (1.07–1.32)

1.17 (1.05–1.30)

1.02 (1.01–1.04)

CVAI

1.21 (1.08–1.37)

1.18 (1.05–1.34)

1.03 (1.01–1.04)

LAP

1.01 (0.92–1.12)

0.99 (0.89–1.10)

1.02 (1.01–1.04)

TyG

1.02 (0.89–1.16)

0.99 (0.86–1.12)

1.03 (1.01–1.05)

TyG-BMI

1.18 (1.06–1.31)

1.15 (1.03–1.28)

1.03 (1.01–1.04)

TyG-WC

1.21 (1.08–1.36)

1.17 (1.04–1.32)

1.03 (1.01–1.06)

TyG-WtHR

1.17 (1.04–1.33)

1.13 (1.00–1.29)

1.03 (1.01–1.06)

CVD

BMI

1.22 (1.13–1.33)

1.20 (1.10–1.30)

1.02 (1.01–1.03)

WC

1.30 (1.18–1.43)

1.26 (1.15–1.39)

1.03 (1.01–1.04)

WtHR

1.25 (1.14–1.38)

1.22 (1.11–1.35)

1.03 (1.01–1.04)

BRI

1.25 (1.14–1.37)

1.22 (1.11–1.34)

1.02 (1.01–1.04)

CVAI

1.30 (1.17–1.44)

1.26 (1.14–1.40)

1.03 (1.01–1.05)

LAP

1.10 (1.02–1.19)

1.07 (0.99–1.16)

1.02 (1.01–1.04)

TyG

1.11 (1.00–1.24)

1.07 (0.96–1.20)

1.04 (1.02–1.06)

TyG-BMI

1.26 (1.15–1.38)

1.22 (1.12–1.34)

1.03 (1.01–1.05)

TyG-WC

1.32 (1.19–1.47)

1.28 (1.15–1.42)

1.04 (1.02–1.06)

TyG-WtHR

1.29 (1.16–1.44)

1.24 (1.11–1.38)

1.04 (1.02–1.06)