The association between different insulin resistance surrogates and all-cause mortality and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease

Table 2 Threshold effect analysis of the different IR surrogates on all-cause mortality in MASLD patients using the two-piecewise linear regression model

Variables	HR (95%CI)	P value
HOMA_IR
Fitting model by standard linear regression	1.016 (0.009–1.023)	0.1
Fitting model by two-piecewise linear regression
Inflection point	3.09
HOMA_IR < 3.09	0.47 (0.237–1.033)	0.31
HOMA_IR > 3.09	1.017 (0.009–1.024)	0.07
P for likelihood ratio test	0.37
TyG
Fitting model by standard linear regression	1.324 (1.167–1.503)	< 0.001
Fitting model by two-piecewise linear regression
Inflection point	8.81
TyG < 8.81	1.078 (0.888–1.309)	0.447
TyG > 8.81	1.777 (1.401–2.253)	< 0.001
P for likelihood ratio test	0.008
TyG_BMI
Fitting model by standard linear regression	1.001 (1–1.002)	0.146
Fitting model by two-piecewise linear regression
Inflection point	270.498
TyG_BMI < 270.498	0.982(0.977–0.988)	< 0.001
TyG_BMI > 270.498	1.003 (1.002–1.005)	< 0.001
P for likelihood ratio test	0.008
TyG_WC
Fitting model by standard linear regression	1.001 (1–1.002)	0.001
Fitting model by two-piecewise linear regression
Inflection point	929.408
TyG_WC < 929.408	0.998 (0.997–1)	0.01
TyG_WC > 929.408	1.002 (1.002–1.003)	< 0.001
P for likelihood ratio test	< 0.001
TyG_WHtR
Fitting model by standard linear regression	1.158 (1.058–1.267)	0.001
Fitting model by two-piecewise linear regression
Inflection point	5.55
TyG_WHtR < 5.55	0.319 (0.197–0.516)	< 0.001
TyG_WHtR > 5.55	1.287 (1.169–1.418)	< 0.001
P for likelihood ratio test	< 0.001

IR, insulin resistance; MASLD, metabolic dysfunction-associated steatotic liver disease; HR, hazard ratio; CI, confidence interval; HOMA-IR, homeostatic model assessment for IR; TyG, triglyceride-glucose; TyG-BMI, TyG-body mass index; TyG-WC, TyG-waist circumference; TyG-WHtR, TyG-waist-to-height ratio;

ISSN: 1475-2840