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Table 1 Clinical, echocardiographic, and medication characteristics of HFpEF patients with and without diabetes mellitus

From: Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets

HF phenotype

HFpEF-non DM

HFpEF-DM

number of the Patient

n = 15

n = 10

Age

75.27 ± 2.06

70.88 ± 2.08

Gender % (M = male)

M = 13.3%

M = 10%

BMI (kg/m2)

32.96 ± 2.26

32.35 ± 2.16

SBP (mmHg)

145.73 ± 4.47

146.38 ± 7.16

DBP (mmHg)

77.13 ± 2.24

75.75 ± 2.96

Hb (g/dL)

8.62 ± 0.19

7.81 ± 0.25

Creatinin (mmol/L)

80.73 ± 5.35

115.38 ± 29.54

eGFR (CKD-EPI) (ml/min/1.73m2)

64.86 ± 3

54.29 ± 11.54

NTproBNP (pmol/l)

34.07 ± 6.47

53.88 ± 24.88

CRP (mg/L)

4.26 ± 1.11

2.83 ± 0.93

LVMI (g/m2)

84.86 ± 5.79

91.63 ± 8.21

LVEF (%)

59.69 ± 2.86

59.64 ± 2.94

E/e' mean ratio

11.95 ± 0.89

14.04 ± 1.3

LAVI max (ml/m2)

53.13 ± 5.75

45.8 ± 3.59

Loop diuretic

9/15

5/10

Thiazide diuretic

2/15

0/10

MRA

6/15

4/10

Bblocker

6/15

6/10

ACEi

2/15

1/10

ARB

8/15

4/10

SGLT2i

14/15

7/10

Statin

8/15

7/10

Oral anti-glycaemic agent

0/15

6/10

Insulin

0/15

4/10

  1. Number of patient (n), Age (years), gender % (M = male), Body mass index (BMI, kg/m2), Systolic blood pressure (SBP, mmHg), Diastolic blood pressure (DBP, mmHg), Hemoglobin (Hb, g/dL), Creatinine (µmol/L), Estimated glomerular filtration rate (eGFR, mL/min/1.73 m2), N-terminal pro-brain natriuretic peptide (NT-proBNP, pmol/L), C-reactive protein (CRP, mg/L), Left ventricular mass index (LVMI, g/m2), Left ventricular ejection fraction (LVEF, %), E/e' mean (ratio of early mitral inflow velocity to mitral annular early diastolic velocity), Maximum left atrial volume index (LAVI max, mL/m2), Loop diuretic, Thiazide diuretic), Mineralocorticoid receptor antagonist (MRA), Beta-blocker (Bblocker), Angiotensin-converting enzyme inhibitor (ACEi), Angiotensin II receptor blocker (ARB), Sodium-glucose cotransporter-2 inhibitor (SGLT2i), Statin, Oral anti-glycaemic agent (OAG), Insulin. Values are given as mean ± SEM or number