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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets

Fig. 6

MAPKs and GSK3β in Left Ventricular Biopsies from Patients with HFpEF, with (+ DM) and without Concomitant Diabetes (-DM). A Schematic representation of the PI3K/AKT/ERK signaling pathway. AKT: AKT serine/threonine kinase; ERK1/2: extracellular-signal regulated kinases; GSK-3: glycogen synthase kinase 3; MEK: mitogen-activated protein kinase; PI3K: phosphatidylinositol-3-kinase; PIP2: phosphatidylinositol-4,5-bisphosphate; PIP3: phosphatidylinositol-3,4,5-trisphosphate; B Expression of GSK3β over GAPDH. C Expression of MAPK p38 over GAPDH. D Expression of ERK2 over GAPDH. E MAPK1 mRNA level. F MAPK3 mRNA level. Data are represented as box and whisker plots (median, 25th to 75th percentiles, minimum, and maximum (n = 6–10 samples/group). P-values are derived from an unpaired t-test; ** P < 0.01

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Cardiovascular Diabetology

ISSN: 1475-2840