Fig. 4
From: Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy
Blood BCAA levels were increased in A-PDK1KO mice. A Heatmap of amino acid concentrations in mouse blood, shown as log2-fold changes. The values are normalized to the median of each amino acid concentration (n = 5, each group). B Blood concentrations of BCAAs (leucine (Leu), isoleucine (Ile), and valine (Val)) and BCKAs (α-keto-isocaproate (KIC), α-keto-β-methylvalerate (KMV), and α-keto-isovalerate (KIV)) were determined by LC‒MS (n = 6 per group). The data are shown as means ± SEs. Significance was calculated by the unpaired Student’s t test or the Mann–Whitney U test, as appropriate. *p value < 0.05, and **p value < 0.01