Parameters | Total (n = 203) | No-HFpEF (n = 129) | HFpEF (n = 74) | χ2/t/Z value | P value |
---|---|---|---|---|---|
Male [n(%)] | 148 (73.40) | 97 (75.19) | 51 (68.92) | 0.937 | 0.333 |
Age (years) | 55.13 ± 13.17 | 53.81 ± 13.622 | 57.45 ± 12.09 | 1.908 | 0.058 |
BMI (kg/m2) | 23.70 (21.90, 26.20) | 23.40 (21.60, 25.55) | 24.40(22.23, 26.73) | − 1.986 | 0.047* |
Smoke [n (%)] | 92 (45.32) | 56 (43.41) | 36 (48.65) | 0.521 | 0.471 |
Hypertension [n (%)] | 114 (56.16) | 70 (54.26) | 44 (59.46) | 0.158 | 0.166 |
Diabetes [n (%)] | 56 (27.59) | 27 (20.93) | 29 (39.19) | 7.848 | 0.005* |
Systolic pressure (mmHg) | 130.00 ± 21.47 | 130.32 ± 21.68 | 129.46 ± 21.24 | − 0.273 | 0.785 |
Diastolic pressure (mmHg) | 80.66 ± 14.53 | 80.77 ± 13.98 | 80.47 ± 15.54 | − 0.139 | 0.890 |
Pulse pressure (mmHg) | 47.00 (39.00, 58.00) | 46.00 (38.50, 56.50) | 47.00 (39.75, 59.00) | − 0.283 | 0.777 |
NYHA | Â | Â | Â | 5.952 | 0.051 |
I | 120 (59.11) | 77 (59.69) | 43 (58.11) | Â | Â |
II | 77 (37.93) | 51 (39.53) | 26 (5.13) | Â | Â |
III | 6 (2.96) | 1 (0.78) | 5 (6.76) | Â | Â |
Renal failure [n (%)] | 10 (4.93) | 3 (2.33) | 7 (9.46) | 5.110 | 0.024* |
LDL (mmol/L) | 2.37 (1.86, 3.18) | 2.37 (1.87, 3.17) | 2.29 (1.86, 3.20) | − 0.567 | 0.571 |
HDL (mmol/L) | 1.11 (0.94, 1.24) | 1.10 (0.95, 1.26) | 1.13 (0.92, 1.20) | − 0.562 | 0.574 |
TC (mmol/L) | 4.04 (3.33, 4.88) | 4.03 (3.35, 4.88) | 4.10 (3.23, 4.92) | 0.528 | 0.598 |
TG (mmol/L) | 1.56 (1.12, 2.24) | 1.63 (1.20, 2.40) | 1.40 (0.86, 2.05) | − 2.105 | 0.035* |
NHR | 0.22 (0.16, 0.28) | 0.21 (0.16, 0.27) | 0.24 (0.17, 0.34) | − 2.582 | 0.010* |
MHR | 0.02 (0.02, 0.03) | 0.02 (0.02, 0.03) | 0.03 (0.02, 0.04) | − 2.223 | 0.026* |
LHR | 0.09 (0.07, 0.12) | 0.09 (0.06, 0.12) | 0.10 (0.07, 0.14) | − 1.752 | 0.080 |
NLR | 2.31 (1.78, 3.23) | 2.22 (1.78, 3.07) | 2.50 (1.75, 3.50) | − 1.059 | 0.290 |
SIRI | 1.05 (0.75, 1.64) | 1.02 (0.73, 1.46) | 1.20 (0.81, 1.96) | − 1.804 | 0.071 |
White blood cell (10*9/L) | 7.18 (6.01, 8.33) | 7.12 (5.96, 7.95) | 7.38 (6.15, 9.02) | − 2.256 | 0.024* |
Neutrophils (10*9/L) | 4.20 (3.34, 5.26) | 4.06 (3.22, 4.81) | 4.58 (3.59, 5.77) | − 2.494 | 0.013* |
Lymphocyte (10*9/L) | 1.82 (1.37, 2.25) | 1.80 (1.34, 2.19) | 1.84 (1.40, 2.35) | − 1.251 | 0.211 |
Monocyte (10*9/L) | 0.46 (0.37, 0.57) | 0.45 (0.37, 0.53) | 0.51 (0.38, 0.65) | − 2.176 | 0.030* |
Eosinophils (10*9/L) | 0.12 (0.07, 0.20) | 0.12 (0.07, 0.22) | 0.11 (0.58, 0.17) | − 1.835 | 0.067 |
Basophil granulocyte (10*9/L) | 0.02 (0.02, 0.04) | 0.02 (0.02, 0.04) | 0.02 (0.01, 0.03) | − 1.109 | 0.268 |
Red blood cell (10*9/L) | 4.84 (4.46, 5.24) | 4.82 (4.45, 5.24) | 4.86 (4.50, 5.24) | − 0.236 | 0.814 |
Urea (mmol/L) | 4.93 (4.16, 6.10) | 4.88 (4.05, 5.87) | 5.24 (4.37, 6.36) | − 1.255 | 0.210 |
Creatinine (µmol/L) | 78.00 (68.00, 92.00) | 77.00 (68.00, 90.50) | 80.00 (66.50, 93.00) | − 0.651 | 0.515 |
Total EAT (mL) | 64.82 ± 20.65 | 62.18 ± 19.93 | 69.43 ± 21.21 | 2.437 | 0.016* |
EAT/BSA | 37.68 (26.95, 46.72) | 37.50 (26.21, 45.94) | 39.48 (29.78, 50.48) | − 1.631 | 0.103 |
LV EAT (mL) | 22.62 ± 8.02 | 21.37 ± 8.13 | 24.81 ± 7.39 | 3.003 | 0.003* |
RV EAT (mL) | 42.20 ± 14.27 | 40.81 ± 13.68 | 44.61 ± 15.03 | 1.838 | 0.068 |
EAT entropy | 6.53 (6.25, 7.03) | 6.75 (6.26, 7.15) | 6.40 (6.22, 6.86) | − 2.242 | 0.025* |
LVEF (%) | 60.00 (52.00, 65.00) | 62.00 (47.50, 67.00) | 57.50 (55.00, 63.00) | − 1.173 | 0.241 |
LADSV (mL) | 27.11 (18.42, 37.56) | 26.24 (17.97, 36.75) | 29.14 (21.18, 40.83) | − 1.654 | 0.100 |
LAESV(mL) | 53.18 (40.42, 67.38) | 51.24 (39.46, 64.44) | 56.18 (42.13, 73.00) | − 2.033 | 0.042* |
EDVI(mL/m2) | 75.09 (61.53, 93.83) | 75.88 (61.18, 94.33) | 74.72 (61.32, 93.31) | − 0.159 | 0.874 |
ESVI(mL/m2) | 36.09 (25.76, 55.56) | 35.35 (23.69, 57.58) | 38.23 (29.90, 52.71) | − 0.997 | 0.319 |
LACI(%) | 19.65 (15.24, 28.28) | 19.23(15.19,26.29) | 23.45 (15.49, 33.42) | − 2.316 | 0.021* |
CO(L/min) | 4.29 ± 1.52 | 4.25 ± 1.46 | 4.35 ± 1.62 | 0.436 | 0.663 |
CI (L/(min m2)) | 2.50 (1.98, 3.07) | 2.48 (1.99, 3.05) | 2.57 (1.91, 3.08) | − 0.309 | 0.757 |
IS(%) | 13.72 (7.02, 20.50) | 13.45 (5.73, 20.88) | 13.78 (9.20, 20.15) | − 0.443 | 0.658 |
GRS(%) | 23.33 (16.97, 30.38) | 24.60 (16.55, 30.14) | 22.23 (17.92, 31.17) | − 0.592 | 0.554 |
GCS(%) | − 16.0 6(− 18.74, − 12.08) | − 16.38 (− 19.24, − 10.98) | − 15.84 (− 17.92, − 13.55) | − 0.216 | 0.829 |
GLS(%) | − 11.15 ± 3.69 | − 11.04 ± 3.94 | − 11.34 ± 3.23 | − 0.571 | 0.568 |
Mitral regurgitation [n (%)] | Â | Â | Â | 3.587 | 0.310 |
No | 75 (36.95) | 53 (41.09) | 22 (29.73) | Â | Â |
Little | 21 (10.34) | 12 (9.30) | 9 (12.16) | Â | Â |
Mild | 100 (49.26) | 61 (47.29) | 39 (52.70) | Â | Â |
Moderate | 7 (3.45) | 3 (2.33) | 4 (5.41) | Â | Â |
Tricuspid regurgitation [n (%)] | Â | Â | Â | 3.247 | 0.355 |
No | 79 (38.92) | 53 (41.09) | 26 (35.14) | Â | Â |
Little | 14 (6.90) | 8 (6.20) | 6 (8.11) | Â | Â |
Mild | 106 (52.22) | 67 (51.94) | 39 (52.70) | Â | Â |
Moderate | 4 (1.97) | 1 (0.78) | 3 (4.05) | Â | Â |
Aortic regurgitation [n (%)] | Â | Â | Â | 0.850 | 0.838 |
No | 125 (61.58) | 81 (62.79) | 44 (59.46) | Â | Â |
Little | 38 (18.72) | 22 (17.05) | 16 (21.62) | Â | Â |
Mild | 38 (18.72) | 25 (19.38) | 13 (17.57) | Â | Â |
Moderate | 2 (0.99) | 1 (0.78) | 1 (1.35) | Â | Â |
Pulmonary hypertension [n (%)] | 18 (8.87) | 9 (6.98) | 9(12.16) | 1.565 | 0.211 |
Pathological vascular branch [n (%)] | Â | Â | Â | 7.445 | 0.059 |
0 | 24 (11.82) | 19 (14.73) | 5 (6.76) | Â | Â |
1 | 112 (55.17) | 75 (58.14) | 37 (50.00) | Â | Â |
2 | 51 (25.12) | 28 (21.71) | 23 (31.08) | Â | Â |
3 | 16 (7.88) | 7 (5.43) | 9 (12.16) | Â | Â |
Pathological vascular [n (%)] | Â | Â | Â | Â | Â |
LAD | 123 (60.59) | 74 (57.36) | 49 (66.22) | 1.543 | 0.214 |
LCX | 69 (33.99) | 39 (30.23) | 30 (40.54) | 2.227 | 0.136 |
RCA | 70 (34.49) | 39 (30.23) | 31 (41.89) | 2.830 | 0.093 |
β-blockers [n (%)] | 179 (88.18) | 112 (86.82) | 67 (90.54) | 0.624 | 0.430 |
ARNI [n (%)] | 59 (29.06) | 35 (27.13) | 24 (32.43) | 0.641 | 0.423 |
ACEI [n (%)] | 65 (32.02) | 37 (28.68) | 28 (37.84) | 1.811 | 0.178 |
ARB [n (%)] | 27 (13.31) | 18 (13.95) | 9 (12.16) | 0.131 | 0.718 |
Statins [n (%)] | 189 (93.10) | 118 (91.47) | 71 (95.95) | 1.465 | 0.226 |
Diuretics [n (%)] | 63 (31.03) | 38 (29.46) | 25 (33.78) | 0.411 | 0.521 |
ASA [n (%)] | 173 (85.22) | 111 (86.05) | 62 (83.78) | 0.191 | 0.662 |
CLO [n (%)] | 129 (63.55) | 82 (63.57) | 47 (63.51) | 0.000 | 0.994 |
TMZ [n (%)] | 82 (40.39) | 51 (39.53) | 31 (41.89) | 0.109 | 0.742 |
DIG [n (%)] | 16 (7.88) | 10 (7.75) | 6 (8.12) | 0.008 | 0.928 |