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Table 2 Cox regression models of the primary outcome, diabetes and albuminuria combined groups, diabetes, and albuminuria

From: Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction

  

Crude model

Fully adjusted model

DM

DM

2.20 (1.44–3.36)

1.93 (1.25–2.97)

Age (per 1 year)

1.03 (0.99–1.06)

Female sex

0.56 (0.37–0.85)

NT-proBNP (per 10 pg/mL)

1.00 (1.00–1.03)

eGFR (per 100 mL/min/1.73m2)

0.89 (0.78–1.00)

AF

1.19 (0.77–1.84)

Albuminuria

Albuminuria

1.76 (1.18–2.64)

1.58 (1.04–2.41)

Age

1.03 (0.99–1.07)

Female

0.58 (0.38–0.88)

NT-proBNP (per 100 pg/mL)

1.00 (1.00–1.03)

eGFR (per 10 mL/min/1.73m2)

0.88 (0.78–1.00)

AF

1.28 (0.83–1.97)

By subgroup

DM−/ALB−

reference

reference

DM+ /ALB−

2.08 (1.20–3.61)

1.93 (1.10–3.36)

DM−/ALB+ 

1.62 (0.79–3.32)

1.58 (0.77–3.26)

DM+ /ALB+ 

3.53 (2.00–6.22)

2.85 (1.57–5.15)

Age

1.05 (1.02–1.08)

1.03 (1.00–1.07)

Female sex

0.58 (0.38–0.86)

0.59 (0.39–0.89)

NT-proBNP (per 100 pg/mL)

1.02 (1.01–1.03)

1.00 (1.00–1.03)

eGFR per 10 mL/min/1.73m2)

0.82 (0.74–0.92)

0.90 (0.80–1.02)

AF

1.49 (0.99–2.25)

1.22 (0.79–1.89)

  1. Values are depicted in hazard ratios with 95% confidence intervals. The crude model includes unadjusted univariable analyses. Confounder covariates are included only in the final model to minimize redundancy. The fully adjusted model includes the covariates age, sex, atrial fibrillation, eGFR, and NT-proBNP. The covariates body mass index, significant coronary artery disease, and sleep apnea were not associated with adverse outcomes in either of the presented models.
  2. AF: atrial fibrillation, ALB: albuminuria, DM: diabetes mellitus, eGFR: estimated glomerular filtration rate, NT-proBNP: N-terminal prohormone brain natriuretic peptide.