Fig. 1
From: Metabolic rewiring and inter-organ crosstalk in diabetic HFpEF
Multisystemic changes in diabetic HFpEF. HFpEF is a multisystemic syndrome featuring prominent extracardiac involvement (e.g., liver, intestine, hematopoietic system and adipose tissue). Comprehensive treatment strategies targeting multiple systems may yield better outcomes. BAT, brown adipose tissue; GMB, gut microbiota; HFpEF, heart failure with preserved ejection fraction; NASH, nonalcoholic steatohepatitis; SCFAs, short-chain fatty acids; WAT, white adipose tissue