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Table 2 Lipids significantly associated with SCA presence. All lipids were manually annotated using MS/MS data

From: Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes

mz

rt

Lipids

q-value

Beta

n

Analysis

1289.1869

597.06

Dimer(CE(18:2):CE(16:1)) + NH4

0.037; 0.048

0.84 [0.45,1.23]; 0.68 [0.34,1.03]

285; 144

T2D no DLP; T2D

502.2925

107.44

LPE(O-20:5);(O) + H

0.036

0.81 [0.39,1.24]

285

Smokers with T2D

504.3084

130.8

LPE(20:3) + H

0.033

0.88 [0.44,1.31]

282

Smokers with T2D

524.2746

107.19

PE(20:4) + Na

0.036

0.82 [0.38,1.26]

285

Smokers with T2D

572.3709

153.57

LPC(22:4) + H

0.033

0.79 [0.42,1.17]

285

Smokers with T2D

578.5869

517.93

Mix Cer(38:1);

O − main Cer(m18:1/20:0) + H

0.042

0.59 [0.27,0.92]

264

Smokers with T2D

601.5185

601.59

DG(18:1_18:2) − H2O + H

0.048

− 0.69 [− 1.06,− 0.32]

139

T2D

640.6023

596.54

CE(16:1) + NH4

0.036; 0.044; 0.037

0.8 [0.38,1.22]; 0.74 [0.38,1.1]; 0.92 [0.51,1.33]

244; 135; 244

Smokers with T2D; T2D; T2D no DLP

732.5531

459.75

PC(32:1) + H

0.036

0.72 [0.33,1.1]

285

Smokers with T2D

748.5472

427.64

PC(32:1);O + H

0.036

0.79 [0.39,1.19]

285

Smokers with T2D

820.5834

461.35

PC(39:6) + H

0.046

− 0.75 [− 1.16,− 0.33]

285

Smokers with T2D

838.6313

499.04

PC(40:4) + H

0.033

0.84 [0.43,1.26]

285

Smokers with T2D

846.5993

428.71

PC(41:7) + H

0.036

− 0.89 [− 1.34,− 0.44]

259

Smokers with T2D

866.6634

514.92

PC(42:4) + H

0.033

0.85 [0.43,1.27]

279

Smokers with T2D

884.7695

587.96

TG(18:2_17:1_18:2) + NH4

0.038

− 0.8 [− 1.24,− 0.37]

285

Smokers with T2D

886.7851

597.06

TG(18:2_18:2_17:0) + NH4

0.048; 0.048

− 0.67 [− 1.02,− 0.31]; − 0.78 [− 1.22,− 0.34]

144; 285

T2D; Smokers with T2D

886.7851

597.06

TG(18:2_18:1_17:1) + NH4

0.048; 0.048

− 0.67 [− 1.02,− 0.31]; − 0.78 [− 1.22,− 0.34]

144; 285

T2D; Smokers with T2D

  1. m/z, mass-to-charge ratio value; rt, retention time; q-value, list of corrected p-values for each analysis where the lipid is considered to be significant, the p-values are obtained from the student’s t-tests performed in linear models; Beta, list of linear regressors for each significant analysis with their 95% confidence interval between brackets; n, number of observations in each model; Analysis, analysis where the lipid is considered significant (subjects with T2D—T2D, subjects with T2D without dyslipidemia—T2D no DLP, and smokers with T2D—Smokers with T2D). All lipids were acquired in positive acquisition mode
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Cardiovascular Diabetology

ISSN: 1475-2840