Table 5 Difference between baseline and after 1 mo of treatment in HFpEF patients
Baseline | Follow-up | p-value | |
|---|---|---|---|
General characteristics | |||
Weight (kg) | 67.30 [51-84.10] | 65.50 [54–87] | 0.122 |
SBP (mmHg) | 135 [103–150] | 120 [104–141] | 0.030 |
DBP (mmHg) | 70 [55–90] | 72 [47–90] | 0.101 |
HR (bpm) | 61 [55–90] | 66 [47–99] | 0.170 |
6MWT (m) | 390 [120–480] | 335 [120–540] | 0.438 |
Sat% O2 at basal time | 97 [95–100] | 97 [94–100] | 0.337 |
Sat% O2 at 6 min | 97 [95–98] | 97 [94–99] | 0.613 |
Biochemical parameters | |||
Hb (g/dL) | 12.80 [9.60–14.60] | 12.95 [9.70–15.40] | 0.342 |
HCT (%) | 39.80 [30.30–44.40] | 40 [29.80–47.90] | 0.517 |
Creatinine (mg/dL) | 0.91 [0.75–2.04] | 1.05 [0.77–1.68] | 0.539 |
eGFR (mL/min/1.73m2) | 64 [30-89.10] | 55.40 [37.30–88.30] | 0.125 |
NT-proBNP (pg/mL) | 870 [231–6631] | 384 [146.60–1803] | 0.219 |
Fasting blood glucose (mg/dL) | 88 [81–108] | 88 [65–110] | 0.837 |
Glycated hemoglobin (%) | 6 [5.12–6.40] | 5.80 [5.10–6.70] | 0.742 |
Echocardiography parameters | |||
EDV (mL) | 94.60 [62.60–155] | 89.50 [60–150] | 0.077 |
ESV (mL) | 40.60 [26.60–71.30] | 38.20 [26-77.90] | 0.056 |
LVMi (g/m2) | 90.45 [52.50-121.50] | 94.68 [53.43-123.39] | 0.246 |
EF (%) | 55.90 [51–60] | 58 [51.90–62.80] | 0.085 |
LVGLS (%) | 18.70 [15.80–22.90] | 18.25 [15-23.20] | 0.946 |
E wave (cm/sec) | 78.60 [47.20–130] | 81.80 [43.50–121] | 0.935 |
A wave (cm/sec) | 87 [44.50–135] | 78.90 [58.20–135] | 0.811 |
E/A | 0.80 [0.60–1.30] | 0.75 [0.70–1.10] | 0.090 |
Sept E’(cm/sec) | 7.62 [5.33–17.70] | 7.65 [12.60;5.55] | 0.764 |
Lat E’(cm/sec) | 8.95 [3.92–12.40] | 9.14 [5.44–14.50] | 0.758 |
E/E’ | 9.20 [6.30–17.60] | 8.30 [5.40–17.90] | 0.935 |
LAVi (ml/m2) | 41.37 [26.15-63] | 40.32 [23.29–62.25] | 0.005 |
PALS (%) | 21.70 [8.10–46.50] | 24 [4.30–60.50] | 0.216 |
LACD(%) | 10.50 [5-25.10] | 11.70 [2.90–41.60] | 0.535 |
LACT(%) | 9.50 [0.60–21.40] | 11.20 [1.60–21.60] | 0.464 |
RAVi (ml/m2) | 20 [13–31] | 21 [15–30] | 0.758 |
RVLS free wall (%) | 22.60 [11.60-27.74] | 22.70 [15.9–30.60] | 0.452 |
RVLS Global (%) | 19.30 [10.30–22.90] | 19.70 [11.30–27.70] | 0.268 |
TAPSE (mm) | 22 [18–28] | 22 [20–28] | 0.720 |
RV S’ (cm/s) | 12.60 [11.20–25] | 12.60 [10-24.50] | 0.518 |
peak TR vel (m/sec) | 2.61 [1.30–3.20] | 2.21 [1.67–2.92] | 0.108 |
PASP (mmHg) | 32 [15–40] | 26 [16–38] | 0.134 |
TAPSE/PASP (mm/mmHg) | 0.73 [0.53–1.49] | 0.87 [0.60–1.25] | 0.154 |
NICaS parameters | |||
MAP (mmHg) | 94 [74–109] | 85 [68–106] | 0.046 |
CI (l/min/m2) | 2.10 [1.53–3.70] | 2.25 [1.32–3.68] | 0.130 |
CO (l/min) | 3.77 [2.59–5.47] | 3.81 [2.14–5.58] | 0.136 |
Stroke volume (ml) | 54.96 [41.05–76.08] | 56.20 [36.88–84.41] | 0.424 |
Stroke volume index (ml/m2) | 32.82 [23.06–48.69] | 31.86 [23.24–49.34] | 0.359 |
CPi (w/m2) | 0.44 [0.29–0.61] | 0.44 [0.20–0.60] | 0.974 |
TPR (dn*s/cm5) | 2073 [1082–2767] | 1676 [1061–2863] | 0.009 |
TPRi (dn*s/cm3) | 3681 [1600–5024] | 3085 [1608–4684] | 0.005 |
GGI | 9.30 [5.83–17.70] | 9.65 [8-18.90] | 0.164 |
RR (l/min) | 16 [11–21] | 16 [11–24] | 0.628 |
TBW (kg) | 40.80 [33.20–58.10] | 41.86 [31.60–48.30] | 0.524 |
TBW (% weight) | 62 [49.40–77.50] | 60.10 [49.80-73.45] | 0.957 |
Basal impedence (ohm) | 311 [226–385;] | 317 [283–410] | 0.610 |