Table 4 Difference between baseline and after 1 mo of treatment in HFrEF/HFmrEF patients
Baseline | Follow-up | p-value | |
|---|---|---|---|
General characteristics | |||
Weight (kg) | 68 [46-99.20] | 66 [46.30–97] | 0.019 |
SBP (mmHg) | 125 [100–140] | 110 [100–140] | 0.318 |
DBP (mmHg) | 69 [63–80] | 68 [45–89] | 0.498 |
HR (bpm) | 67 [54–83] | 61 [53–93] | 0.777 |
6MWT (m) | 420 [120–480] | 435 [120–510] | 0.193 |
Sat% O2 at basal time | 96 [94–100] | 98 [95–100] | 0.334 |
Sat% O2 at 6 min | 97 [88–99] | 97.50 [94–99] | 0.439 |
Biochemical parameters | |||
Hb (g/dL) | 13.30 [9.90–15.50] | 14.40 [10.40–15.40] | 0.040 |
HCT (%) | 40.80 [32.60–44.50] | 40.80 [33.60–45.10] | 0.424 |
Creatinine (mg/dL) | 1.05 [1.00-1.46] | 1.06 [0.97–1.53] | 0.699 |
Azotemia (mg/dL) | 49 [35–52] | 44 [39–46] | 0.945 |
eGFR (mL/min/1.73m2), | 59.30 [36–90] | 67.50 [47-82.20] | 0.361 |
NT-proBNP (pg/mL), | 1759 [296–7287] | 1326 [237–8927] | 0.594 |
Fasting blood glucose (mg/dL) | 94 [76–133] | 92.50 [72–143] | 0.895 |
Echocardiography parameters | |||
EDV (mL) | 130 [86–240] | 143 [85–236] | 0.744 |
ESV (mL) | 65.50 [44–193] | 71.60 [44–169] | 0.352 |
LVMi (g/m2) | 111 [76–158] | 104 [56–202] | 0.726 |
EF (%) | 43.40 [19.60–49.60] | 41 [22-53.40] | 0.296 |
LVGLS (%) | 10.20 [4.80–15.40] | 10.20 [4.70–16.70] | 0.570 |
E wave (cm/sec) | 76.50 [37.20–111] | 79 [33–109] | 0.628 |
A wave (cm/sec) | 79.10 [34.60–91.70] | 74.40 [35.60–97.50] | 0.502 |
E/A | 0.80 [0.40–2.30] | 0.80 [0.40–1.90] | 0.740 |
Sept E’(cm/sec) | 6.10 [3.10–10.60] | 6.10 [3.26–8.10] | 0.046 |
Lat E’(cm/sec) | 7.14 [4.80–13.10] | 7.20 [4.13–12.40] | 0.428 |
E/E’ | 12.80 [4.50–18.80] | 11.10 [5.30–21.50] | 0.881 |
LAVi (ml/m2) | 45.50 [38-58.60] | 41 [32-44.90] | 0.021 |
PALS (%) | 11.40 [4.60–22.80] | 14.70 [5.50–22.30] | 0.568 |
LACD(%) | 6.40 [10.50–1.90] | 7 [5.40–10.90] | 0.739 |
LACT(%) | 8.20 [1.40–19.20] | 6.80 [0.80–16.80] | 0.281 |
RAVi (ml/m2) | 23.20 [16.20–44.30] | 20.20 [18–45] | 0.431 |
RVLS free wall (%) | 14.10 [7.2–23.50] | 17.45 [9.70–29.80] | 0.356 |
RVLS Global (%) | 11.40 [5.80–18.10] | 15.50 [7.50–22.80] | 0.268 |
TAPSE (mm) | 23 [21.30–24] | 22.10 [11–26] | 0.983 |
RV S’ (cm/s) | 13.10 [9.20–15.90] | 11.20 [6.70–14] | 0.157 |
peak TR vel (m/sec) | 2.52 [1.76–2.76] | 2.20 [1.44–2.53] | 0.139 |
PASP (mmHg) | 30 [23–38] | 25 [15–33] | 0.013 |
TAPSE/PASP (mm/mmHg) | 0.85 [0.69–0.96] | 0.76 [0.33–1.73] | 0.255 |
NICaS parameters | |||
MAP (mmHg) | 91 [76–96] | 76 [63–104] | 0.200 |
CI (l/min/m2) | 1.85 [1.46–2.85] | 2.04 [1.42–2.75] | 0.453 |
CO (l/min) | 3.83 [2.54–4.48] | 3.56 [2.87–5.37] | 0.503 |
Stroke volume (ml) | 57.17 [32.94–70.45] | 61.21 [40.42–93.13] | 0.539 |
Stroke volume index (ml/m2) | 28.21 [18.95–44.55] | 31.09 [26.36–44.06] | 0.695 |
CPi (w/m2) | 0.39 [0.23–0.58] | 0.38 [0.24–0.62] | 0.834 |
TPR (dn*s/cm5) | 1867 [1577–2475] | 1893 [1259–2123] | 0.191 |
TPRi (dn*s/cm3) | 3545 [2582–4611] | 3112 [2660–4271] | 0.147 |
GGI | 8.80 [6.85–15.35] | 10.60 [7.66–12.79] | 0.507 |
RR (l/min) | 18 [14–20] | 17 [12–20] | 0.396 |
TBW (kg) | 50.63 [31.83-65] | 42.13 [30.60-55.68] | 0.050 |
TBW (% weight) | 66.33 [51.45–74.45] | 58.68 [55.13–66.50] | 0.047 |
Basal impedence (ohm) | 321 [226–391] | 386 [244–407] | 0.028 |