Table 3 Difference between baseline and after 1 mo of treatment in patients with BMI ≥ 25 kg/m2
Baseline | Follow-up | p-value | |
|---|---|---|---|
General characteristics | |||
Weight (kg) | 77.25 [57.80–99.20;] | 74.05 [57.60–97] | 0.031 |
SBP (mmHg) | 132.50 [110–150] | 122 [104–141] | 0.039 |
DBP (mmHg) | 77.50 [55–90] | 72 [45–90] | 0.088 |
HR (bpm) | 62.50 [55–90] | 66 [47–99] | 0.371 |
6MWT (m) | 375 [120–480] | 405 [120–540] | 0.132 |
Sat% O2 at basal time | 97 [95–100] | 97 [94–100] | 0.836 |
Sat% O2 at 6 min | 97 [96–98] | 97 [94–99] | 0.532 |
Biochemical parameters | |||
Hb (g/dL) | 13 [9.60–15.50] | 13.60 [9.70–15.40] | 0.006 |
HCT (%) | 40.75 [30.30–44.50] | 41.50 [29.80–47.90] | 0.039 |
Creatinine (mg/dL) | 0.92 [0.75–2.04] | 1 [0.77–1.68] | 0.924 |
eGFR (mL/min/1.73m2) | 65 [30–90] | 65.70 [37.30–88.30] | 0.391 |
NT-proBNP (pg/mL) | 609.50 [231–1759] | 381 [146.60–1803] | 0.322 |
Fasting blood glucose (mg/dL) | 90.50 [81–108] | 94.50 [65–110] | 0.894 |
Glycated hemoglobin (%) | 5.85 [5.12–6.40] | 5.60 [4.90–6.70] | 0.751 |
Echocardiography parameters | |||
EDV (mL) | 105.05 [62.60–240] | 93.45 [60–236] | 0.036 |
ESV (mL) | 45.40 [27.60–173] | 39.40 [26–169] | 0.009 |
LVMi (g/m2) | 99.52 [52.52-142.24] | 97.34 [53.43-129.07] | 0.125 |
EF (%) | 54.80 [27.90–60] | 56 [28.40–62.80] | 0.069 |
LVGLS (%) | 17.10 [9.50–22.90] | 17.55 [9.30–21] | 0.487 |
E wave (cm/sec) | 84.95 [37.20–130] | 83.35 [33–121] | 0.437 |
A wave (cm/sec) | 87 [44.50–135] | 75.50 [58.20–135] | 0.611 |
E/A | 0.70 [0.40–1.30] | 0.70 [0.40–1.10] | 0.148 |
Sept E’(cm/sec) | 7.91 [5.33–17.70] | 7.64 [5.55–12.60] | 0.573 |
Lat E’(cm/sec) | 8.03 [3.92–11.70] | 7.63 [5.44–14.50] | 0.726 |
E/E’ | 9.43 [4.50–17.60] | 7.98 [5.30–17.90] | 0.487 |
LAVi (ml/m2) | 44.70 [30-69.40] | 40.50 [29-62.60] | 0.008 |
PALS (%) | 18.45 [8.10–28.30] | 19.25 [4.30–39.20] | 0.351 |
LACD(%) | 9.15 [1.90–21.10] | 9.35 [2.90–23.10] | 0.573 |
LACT(%) | 8.45 [2.10–19.20] | 10.25 [1.60–21.60] | 0.618 |
RAVi (ml/m2) | 21.15 [13-26.10] | 20.10 [15–23] | 0.744 |
RVLS free wall (%) | 21.65 [7.20–27.70] | 21.90 [13.90–29.80] | 0.271 |
RVLS Global (%) | 18.15 [5.80–22.90] | 19.20 [11.30–27.70] | 0.072 |
TAPSE (mm) | 21.60 [18–28] | 22 [17–26] | 0.904 |
RV S’ (cm/s) | 12.60 [11.20–25] | 12.45 [10-24.50] | 0.959 |
peak TR vel (m/sec) | 2.36 [1.30–3.20] | 2.15 [1.44–2.90] | 0.056 |
PASP (mmHg) | 27 [15–40] | 24.50 [15–35] | 0.036 |
TAPSE/PASP (mm/mmHg) | 0.73 [0.53–1.49] | 0.88 [0.60–1.73] | 0.096 |
NICaS parameters | |||
MAP (mmHg) | 95.50 [78–109] | 87.50 [63–106] | 0.043 |
CI (l/min/m2) | 2.07 [1.53–2.25] | 2.20 [1.42–2.77] | 0.082 |
CO (l/min) | 3.77 [2.59–4.48] | 3.91 [2.68–5.37] | 0.120 |
Stroke volume (ml) | 55.58 [41.05–76.08] | 55.02 [36.88–93.13] | 0.276 |
Stroke volume index (ml/m2) | 31.75 [23.06–40.97] | 31.43 [23.24–49.34] | 0.240 |
CPi (w/m2) | 0.43 [0.29–0.49] | 0.42 [0.24–0.62] | 0.937 |
TPR (dn*s/cm5) | 2048.50 [1577–2767] | 1657.50 [1259–2863] | 0.002 |
TPRi (dn*s/cm3) | 3616.50 [2911–5024] | 3098.50 [2400–4684] | 0.001 |
GGI | 9.08 [5.83–13.84] | 9.72 [7.66–13.98] | 0.115 |
RR (l/min) | 16.50 [11–21] | 16 [12–24] | 0.828 |
TBW (kg) | 44.62 [34.95-65] | 45.09 [35.30-55.68] | 0.230 |
TBW (% weight) | 59.75 [49.40-77.46] | 58.83 [49.80–72.50] | 0.601 |
Basal impedence (ohm) | 296.50 [226–384] | 308 [244–373] | 0.297 |