Table 2 Difference between baseline and after 1 mo of treatment with SGLT2i
Baseline characteristics | 30-days post SGLT2i therapy | p-value | |
|---|---|---|---|
General characteristics | |||
Weight (kg) | 67.65 [46-99.20] | 65.50 [46.30–97] | 0.027 |
SBP (mmHg) | 130 [100–150] | 116.50 [100–141] | 0.015 |
DBP (mmHg) | 69.50 [55–90] | 70 [45–90] | 0.097 |
HR (bpm) | 62.50 [54–90] | 65 [47–99] | 0.567 |
6MWT (m) | 390 [120–480] | 390 [120–540] | 0.231 |
Sat% O2 at basal time | 97 [94–100] | 97 [94–100] | 0.878 |
Sat% O2 at 6 min | 97 [88–99] | 97 [94–99] | 0.335 |
Biochemical parameters | |||
Hb (g/dL) | 12.90 [9.60–15.50] | 13.20 [9.70–15.40] | 0.034 |
HCT (%) | 39.90 [30.30–44.50] | 40.40 [29.80–47.90] | 0.293 |
Creatinine (mg/dL) | 0.95 [0.68–2.04] | 1.05 [0.77–1.68] | 0.484 |
eGFR (mL/min/1.73m2) | 62.90 [30-91.50] | 58.50 [37.30–88.30] | 0.589 |
NT-proBNP (pg/mL) | 906.50 [231–7287] | 505 [146.60–8927] | 0.328 |
Fasting blood glucose (mg/dL) | 89 [76–133] | 88 [65–143] | 0.889 |
Glycated hemoglobin (%) | 5.95 [5.12–6.40] | 5.73 [4.90–6.70] | 0.742 |
Echocardiography parameters | |||
EDV (mL) | 97.10 [62.60–155] | 94.05 [60–150] | 0.102 |
ESV (mL) | 45.40 [26.60–71.30] | 41.50 [26-77.90] | 0.042 |
LVMi (g/m2) | 98.44 [49–137] | 99.60 [48–128] | 0.139 |
EF (%) | 53.80 [19.60–65.20] | 54.30 [22-62.80] | 0.045 |
LVGLS (%) | 16.75 [4.80–22.90] | 17.10 [4.70–23.20] | 0.835 |
E wave (cm/sec) | 77.55 [37.20–130] | 80.40 [33–121] | 0.760 |
A wave (cm/sec) | 82.40 [34.60–135] | 75.50 [35.60–135] | 0.955 |
E/A | 0.80 [0.40–2.30] | 0.80 [0.40–1.90] | 0.095 |
Sept E’(cm/sec) | 7.14 [3.10–17.70] | 6.85 [3.26–12.60] | 0.361 |
Lat E’(cm/sec) | 8.71 [3.92–13.10] | 7.73 [4.13–14.50] | 0.938 |
E/E’ | 9.42 [4.50–18.80] | 9.03 [5.30–21.50] | 0.866 |
LAVi (ml/m2) | 42.84 [27-69.40] | 41.15 [26-62.60] | < 0.001 |
PALS (%) | 19.75 [4.60–46.50] | 20.20 [4.30–60.50] | 0.171 |
LACD(%) | 9.60 [1.90–25.10] | 9.35 [2.40–41.60] | 0.821 |
LACT(%) | 8.80 [2.10–21.40] | 10.25 [1.60–21.60] | 0.597 |
RAVi (ml/m2) | 22.50 [13-44.30] | 21 [15–45] | 0.867 |
RVLS free wall (%) | 21.6 [7.20–27.7] | 21.90 [9.70–27.70] | 0.250 |
RVLS Global (%) | 17.90 [5.80–22.90] | 18.20 [7.50–27.70] | 0.072 |
TAPSE (mm) | 22.20 [18–29] | 22 [11–28] | 0.739 |
RV S’ (cm/s) | 12.80 [9.20–25] | 12.35 [6.70–24.50] | 0.822 |
peak TR vel (m/sec) | 2.52 [1.30–3.20] | 2.21 [1.44–2.92] | 0.023 |
PASP (mmHg) | 31 [15–40] | 25.50 [15–38] | 0.010 |
TAPSE/PASP (mm/mmHg) | 0.73 [0.53–1.49] | 0.85 [0.33–1.73] | 0.059 |
NICaS parameters | |||
MAP (mmHg) | 91.50 [74–109] | 83.50 [63–106] | 0.015 |
CI (l/min/m2) | 2.07 [1.46–3.70] | 2.09 [1.32–3.68] | 0.089 |
CO (l/min) | 3.77 [2.54–5.47] | 3.72 [2.14–5.58] | 0.108 |
Stroke volume (ml) | 55.59 [32.94–76.08] | 56.52 [36.88–93.13] | 0.303 |
Stroke volume index (ml/m2) | 31.75 [18.95–48.69] | 31.82 [23.24–49.34] | 0.359 |
CPi (w/m2) | 0.41 [0.25–0.61] | 0.40 [0.20–0.62] | 0.902 |
TPR (dn*s/cm5) | 2048.50 [1082–2767] | 1776 [1061–2863] | 0.004 |
TPRi (dn*s/cm3) | 3616.50 [1600–5024] | 3098.50 [1608–4684] | 0.002 |
GGI | 9.25 [5.83–17.70] | 10.02 [7.70–18.90] | 0.162 |
RR (l/min) | 17 [11–21] | 16 [11–24] | 0.934 |
TBW (kg) | 44.17 [31.80–65] | 42 [30.60–55.70] | 0.081 |
TBW (% weight), | 63.44 [49.40–77.50] | 59.55 [49.80–73.40] | 0.268 |
Basal impedence (ohm) | 311.50 [226–391] | 317 [244–410] | 0.074 |