Table 2 Meta-regression of change in AUC of C-peptide (two factors)

Model 1: cumulative dose combined with age

95.4

 Dose ≥ 25 mg

0.499 (0.221, 0.777)

 < 0.001

 Average age

− 0.023 (− 0.052, 0.006)

0.113

Model 2: cumulative dose combined with T1D diagnosis duration

89.4

 Dose ≥ 25 mg

0.548 (0.217, 0.879)

0.001

 T1D diagnosis duration ≤ 6 weeks, yes

0.133 (− 0.229, 0.496)

0.470