Table 2 The mediation effect of T2D on CHD via proteins
From: Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease
T2D-proteins-CHD | Total effect | Direct effect 1 | Direct effect 2 | Direct effect | Mediation effect | Mediated proportion (%) (95%CI) |
|---|---|---|---|---|---|---|
β | β | β | β | β (95%CI) | ||
PCSK9 | 0.1525 | 0.0404 | 0.2011 | 0.1443 | 0.0081(0.0021, 0.0142) | 5.330(1.368, 9.292) |
NRP1 | 0.1525 | − 0.0338 | − 0.0698 | 0.1501 | 0.0024(0.0010, 0.0037) | 1.546(0.684, 2.408) |
CD27 | 0.1525 | 0.0455 | 0.0338 | 0.1509 | 0.0015(0.0008, 0.0023) | 1.010(0.504, 1.515) |
REN | 0.1525 | − 0.0350 | 0.1915 | 0.1592 | − 0.0067(− 0.0197, 0.0063) | − 4.394(− 12.930, 0.000) |
RNASE1 | 0.1525 | 0.0577 | 0.0383 | 0.1503 | 0.0022(0.0012, 0.0032) | 1.449(0.800, 2.097) |
ANGPTL4 | 0.1525 | 0.0358 | 0.0650 | 0.1501 | 0.0023(0.0003, 0.0044) | 1.526(0.185, 2.866) |
PALM | 0.1525 | − 0.0693 | − 0.0471 | 0.1492 | 0.0033(0.0018, 0.0047) | 2.138(1.194, 3.082) |
RNASE6 | 0.1525 | − 0.0367 | − 0.0135 | 0.1520 | 0.0005(1.9254E−05, 0.0010) | 0.324(0.013, 0.635) |
CYTL1 | 0.1525 | 0.0429 | − 0.0264 | 0.1536 | − 0.0011(− 0.0018, − 0.0005) | − 0.741(− 1.164, − 0.319) |