Cardiovascular abnormalities already occurred in newly-diagnosed patients with early-onset type 2 diabetes

Table 5 Comparison of cluster-specific pPS between normal and carotid artery abnormality in newly diagnosed EOD patients

Cluster	Normal	Carotid artery abnormality	p value	Normal	Plaque formation	p value
n	206	75	281	206	47	253
Lipodystrophy	0.02195 ± 0.0021	0.02250 ± 0.0025	0.062	0.02195 ± 0.0021	0.02263 ± 0.0021	0.048
Obesity	0.01317 ± 0.0006	0.01314 ± 0.0005	0.669	0.01317 ± 0.0006	0.01323 ± 0.0006	0.56
Metabolic_syndrome	0.01883 ± 0.0011	0.01859 ± 0.0009	0.084	0.01883 ± 0.0011	0.01875 ± 0.0009	0.641
Body_fat.	0.01490 ± 0.0008	0.01490 ± 0.0008	0.968	0.01490 ± 0.0008	0.01479 ± 0.0007	0.395
Liver_lipid_metabolism	0.02309 ± 0.0070	0.02399 ± 0.0059	0.318	0.02309 ± 0.0070	0.02377 ± 0.0058	0.537
Beta_cell_+PI	0.02535 ± 0.0033	0.02555 ± 0.0032	0.655	0.02535 ± 0.0033	0.02512 ± 0.0034	0.666
Beta_cell_-PI	0.02660 ± 0.0019	0.02642 ± 0.0016	0.494	0.02660 ± 0.0019	0.02663 ± 0.0014	0.907
Residual_glycaemic	0.01518 ± 0.0007	0.01521 ± 0.0007	0.774	0.01518 ± 0.0007	0.01537 ± 0.0006	0.104
Total_pPS	0.01699 ± 0.0004	0.01698 ± 0.0004	0.850	0.01699 ± 0.0004	0.01704 ± 0.0004	0.519

1. Data were presented as means ± SD for continuous variables
2. P values were for the t-test analyses across the groups. A two-sided test with p < 0.05 was considered statistically significant. The p value of pPS for lipodystrophy between normal and carotid artery abnormality was presented in bold
3. Total_pPS means weighted pPS for 662 type 2 diabetes-associated loci
4. Abbreviation: pPS, the cluster-specific partitioned polygenic scores; PI, proinsulin

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