Table 2 Advanced lipoprotein variables of the LIPOCAT study
Lipid and lipoprotein variables | All | non-CVE | CVE | p-value |
|---|---|---|---|---|
n = 933 | n = 829 | n = 104 | ||
Total lipids | ||||
Total cholesterol (mg/dL) | 177 [155;198] | 207 [154;198] | 178 [163;198] | 0.284 |
Total triglycerides (mg/dL) | 104 [79;142] | 103 [78;140] | 122 [84;147] | 0.017 |
Lipoprotein lipid distribution | ||||
VLDL-C (mg/dL) | 16.8 [11.1;25.0] | 16.6 [10.9;24.3] | 20.7 [12.2;26.6] | 0.031 |
VLDL-TG (mg/dL) | 59.3 [40.8;92.1] | 58.5 [40.9;90.7] | 72.8 [37.8;96.2] | 0.054 |
VLDL-TG/VLDL-C ratio | 3.77 [3.34;4.30] | 3.77 [3.34;4.31] | 3.77 [3.31;4.19] | 0.605 |
IDL-C (mg/dL) | 11.3 [8.04;15.2] | 11.2 [8.00;15.2] | 12.7 [8.72;15.4] | 0.058 |
IDL-TG (mg/dL) | 10.9 [8.14;13.9] | 10.8 [8.06;13.8] | 11.9 [9.06;15.0] | 0.013 |
IDL-TG/IDL-C ratio | 0.95 [0.87;1.06] | 0.95 [0.87;1.06] | 0.94 [0.86;1.06] | 0.879 |
LDL-C (mg/dL) | 92.7 [78.4;109.0] | 82.9 [78.5;109.0] | 91.3 [77.9;107.0] | 0.715 |
LDL-TG (mg/dL) | 13.1 [10.1;16.3] | 12.9 [9.91;16.2] | 14.3 [11.6;17.7] | 0.002 |
LDL-TG/LDL-C ratio | 0.14 [0.12;0.16] | 0.14 [0.11;0.16] | 0.15 [0.13;0.18] | < 0.001 |
HDL-C (mg/dL) | 50.9 [43.8;59.5] | 50.9 [43.8;59.5] | 51.6 [43.9;60.2] | 0.994 |
HDL-TG (mg/dL) | 17.8 [13.4;22.3] | 17.6 [13.2;22.2] | 18.7 [14.8;23.0] | 0.084 |
HDL-TG/HDL-C ratio | 0.34 [0.26;0.44] | 0.34 [0.26;0.43] | 0.37 [0.28;0.45] | 0.084 |
Lipoprotein size distribution | ||||
VLDL diameter (nm) | 42.2 [42.0;42.3] | 42.2 [42.0;42.3] | 42.2 [42.0;42.3] | 0.789 |
VLDL-P (nmol/L) | 45.4 [31.0;67.9] | 44.4 [31.0;67.2] | 56.7 [30.2;71.8] | 0.052 |
Large (nmol/L) | 1.17 [0.91;1.58] | 1.15 [0.91;1.56] | 1.32 [0.91;1.64] | 0.090 |
Medium (nmol/L) | 4.77 [3.21;7.36] | 4.74 [3.21;7.16] | 5.58 [3.43;9.27] | 0.038 |
Small (nmol/L) | 39.3 [26.9;58.9] | 38.7 [26.9;58.7] | 49.2 [26.7;61.1] | 0.060 |
LDL diameter (nm) | 20.8 [20.6;20.9] | 20.8 [20.6;20.9] | 20.9 [20.7;21.0] | 0.078 |
LDL-P (nmol/L) | 705 [609;817] | 708 [607;819] | 696 [617;804] | 0.960 |
Large (nmol/L) | 96.8 [83.5;111.0] | 96.4 [83.1;111.0] | 99.7 [89.9;114.0] | 0.105 |
Medium (nmol/L) | 188 [145;238] | 188 [144;237] | 188 [147;241] | 0.871 |
Small (nmol/L) | 423 [369;477] | 423 [369;478] | 414 [367;477] | 0.498 |
HDL diameter (nm) | 8.20 [8.15;8.24] | 8.19 [8.15;8.24] | 8.22 [8.17;8.26] | 0.004 |
HDL-P (nmol/L) | 29.2 [24.7;34.4] | 29.2 [24.7;34.5] | 29.4 [24.9;34.1] | 0.927 |
Large (nmol/L) | 0.29 [0.25;0.32] | 0.28 [0.25;0.32] | 0.29 [0.27;0.32] | 0.007 |
Medium (nmol/L) | 8.83 [7.82;9.81] | 8.79 [7.80;9.76] | 9.10 [8.08;10.0] | 0.070 |
Small (nmol/L) | 20.2 [16.3;24.5] | 20.3 [16.3;24.6] | 19.8 [16.2;23.9] | 0.413 |
Calculated CV surrogates | ||||
Small HDL-P-to-medium HDL-P | 2.27 [1.95;2.68] | 2.28 [1.98;2.72] | 2.19 [1.87;2.55] | 0.039 |
LDL-P-to-HDL-P | 24.4 [19.8;29.6] | 24.3 [19.9;29.6] | 24.7 [19.8;29.8] | 0.714 |
Total particles-to-HDL-P | 26.2 [21.4;31.6] | 26.0 [21.4;31.5] | 26.7 [21.5;31.8] | 0.496 |
Non-HDL-P (nmol/L) | 728 [635;841] | 726 [634;841] | 729 [650;832] | 0.622 |
HDL-C/total TG | 0.50 [0.34;0.71] | 0.50 [0.34;0.71] | 0.44 [0.30;0.67] | 0.063 |
Cholesterol remnants (Liposcale®; mg/dL) † | 28.7 [20.0;39.4] | 28.5 [20.0;38.6] | 32.7 [21.3;42.9] | 0.019 |
Cholesterol remnants (EAS; mg/dL) ‡ | 29.1 [20.5;39.0] | 28.6 [20.1;38.7] | 33.5 [22.8;42.3] | 0.010 |