Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization

Table 3 Mendelian randomization estimates of the effect of T2DM on TET2-CHIP mutation

ID.exposure	ID outcome	Outcome	Exposure	Method	SNP	B	SE	P value	Lower CI	Upper CI	OR	Lower 95% CI	Upper 95% CI
TET2 CHIP mutations
finngen_finngen_R10_T2D	85glda	GCST90102620	finngen_R10_T2D	MR Egger	352	− 0.00047	0.000974	0.632688	− 0.00238	0.001443	0.999534	0.997628	1.001444
finngen_finngen_R10_T2D	85glda	GCST90102620	finngen_R10_T2D	Weighted median	352	0.001475	0.000832	0.076323	− 0.00016	0.003106	1.001476	0.999844	1.003111
finngen_finngen_R10_T2D	85glda	GCST90102620	finngen_R10_T2D	Inverse variance weighted	352	0.001245	0.000447	0.005331	0.000369	0.002121	1.001246	1.000369	1.002124
finngen_finngen_R10_T2D	85glda	GCST90102620	finngen_R10_T2D	Simple mode	352	0.001742	0.001924	0.365945	− 0.00203	0.005513	1.001743	0.997973	1.005528
finngen_finngen_R10_T2D	85glda	GCST90102620	finngen_R10_T2D	Weighted mode	352	0.001422	0.001191	0.23343	− 0.00091	0.003757	1.001423	0.999087	1.003764

T2DM type 2 diabetes mellitus; CHIP clonal hematopoiesis of indeterminate potential; OR odds ratio; CI confidential interval; SNP single nucleotide polymorphisms; MR Mendelian randomization

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