Table 1 The top up- and downregulated differentially expressed genes in all comparison groups
Gene type | Gene symbol | Gene description | Log2FC | padj |
|---|---|---|---|---|
530Â days male mice ND vs. WD | ||||
Protein coding | Zbed6 | zinc finger, BED type containing 6 | 2.43 | 2.1E-02 |
Slfn3 | schlafen 3 | 2.35 | 1.3E-04 | |
Zbtb37 | zinc finger and BTB domain containing 37 | 1.83 | 4.0E-03 | |
Hipk2 | homeodomain interacting protein kinase 2 | 1.78 | 3.7E-02 | |
Lcor | ligand dependent nuclear receptor corepressor | 1.77 | 1.0E-02 | |
Rgs9 | regulator of G-protein signaling 9 | -2.68 | 5.3E-05 | |
Lars2 | leucyl-tRNA synthetase, mitochondrial | -2.51 | 2.6E-05 | |
Hbb-bt | hemoglobin, beta adult t chain | -2.24 | 1.4E-02 | |
Arntl | aryl hydrocarbon receptor nuclear translocator-like | -2.13 | 7.0E-07 | |
Spon2 | spondin 2, extracellular matrix protein | -2.11 | 2.1E-03 | |
lncRNA | Gm15564 | predicted gene | 1.79 | 3.2E-03 |
| Â | 4632427E13Rik | RIKEN cDNA 4632427E13 gene | 1.63 | 8.6E-03 |
Kcnq1ot1 | KCNQ1 overlapping transcript 1 | 1.55 | 7.0E-04 | |
Lncpint | Trp53 induced transcript | 1.45 | 1.1E-03 | |
5930430L01Rik | RIKEN cDNA 5930430L01 gene | 1.44 | 3.0E-04 | |
Gm27028 | predicted gene | -2.38 | 4.3E-04 | |
Gm14286 | predicted gene | -2.13 | 2.9E-05 | |
Mir17hg | Mir17 host gene (non-protein coding) | -2.07 | 1.5E-04 | |
Gm56503 | predicted gene | -1.91 | 1.3E-04 | |
Gm31619 | predicted gene | -1.89 | 4.9E-04 | |
750Â days male mice ND vs. WD | ||||
Protein coding | Fam107a | family with sequence similarity 107, member A | 1.86 | 6.3E-03 |
Itga2b | integrin alpha 2b | 1.86 | 6.1E-03 | |
Timp4 | tissue inhibitor of metalloproteinase 4 | 1.06 | 3.9E-03 | |
Adh1 | alcohol dehydrogenase 1 (class I) | 1.00 | 3.9E-03 | |
Spock2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 | 0.96 | 1.3E-02 | |
Sema5a | sema domain, seven thrombospondin repeats trans-membrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.95 | 3.9E-03 | |
Efr3b | EFR3 homolog B | -0.66 | 3.6E-02 | |
530Â days female mice ND vs. WD | ||||
Protein coding | Arntl | D site albumin promoter binding protein | 1.47 | 2.0E-02 |
Adam19 | aryl hydrocarbon receptor nuclear translocator-like | 0.85 | 3.3E-02 | |
Ypel2 | a disintegrin and metallopeptidase domain 19 | Â | Â | |
(meltrin beta) | 0.75 | 1.7E-03 | Â | Â |
Mthfr | yippee like 2 | 0.52 | 2.0E-02 | |
Dbp | D site albumin promoter binding protein | -1.16 | 1.3E-02 | |
Bhlhe41 | basic helix-loop-helix family, member e41 | -0.61 | 2.7E-02 | |
Slc45a4 | solute carrier family 45, member 4 | -0.45 | 3.5E-02 | |
Ifrd2 | interferon-related developmental regulator 2 | -0.43 | 2.7E-02 | |
640Â days female mice ND vs. WD | ||||
Protein coding | Arntl | aryl hydrocarbon receptor nuclear translocator-like | 2.22 | 2.5E-07 |
Vwa3a | von Willebrand factor A domain containing 3A | 0.93 | 6.2E-03 | |
Slc41a3 | solute carrier family 41, member 3 | 0.79 | 3.4E-02 | |
Slc7a6 | solute carrier family 7 (cationic amino acid transporter, y + system), member 6 | 0.58 | 4.0E-02 | |
Arrdc4 | arrestin domain containing 4 | 0.56 | 4.0E-02 | |
Rhobtb1 | Rho-related BTB domain containing 1 | -0.86 | 1.7E-02 | |
Adh1 | alcohol dehydrogenase 1 (class I) | -0.86 | 3.0E-02 | |
Tspan4 | tetraspanin 4 | -0.76 | 3.3E-05 | |
Lrrn4cl | LRRN4 C-terminal like | -0.66 | 3.0E-02 | |
Angptl2 | angiopoietin-like 2 | -0.48 | 6.2E-03 | |