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Table 2 Unadjusted and adjusted models of SGLT2i effects on Stroke Risk Stratified by Age groups

From: Age-dependent effects of SGLT2 inhibitors on stroke risk in geriatric patients with diabetes and atrial fibrillation

Age group

Unadjusted model HR (95% CI)

Model 1 h (95% CI)

Model 2 h (95% CI)

Age < 75 years old (n = 4981)

0.71 (0.50-1.00)

0.66 (0.47–0.93)*

0.63 (0.44–0.88)*

Age 75–89 years old (n = 4248)

1.11 (0.71–1.74)

1.00 (0.63–1.58)

0.95 (0.60–1.50)

Age ≥ 90 years old (n = 440)

4.96 (1.19–20.7)*

5.72 (1.34–24.4)*

5.04 (1.20–21.1)*

  1. Model 1: Adjust for individual CHA2DS2-VASc score components and use of oral anticoagulant
  2. Model 2: Adjust for CHA2DS2-VASc score and use of oral anticoagulant
  3. CI confidence interval, HR hazard ratio, SGLT2i sodium-glucose cotransporter 2 inhibitors
  4. *P < 0.05 SGLT2i users vs. non-users
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Cardiovascular Diabetology

ISSN: 1475-2840