Fig. 5

Effects of lipoxin A₄ on cardiac hypertrophy and cardiomyocyte apoptosis in diabetic mice. A mRNA levels of hypertrophic markers. B Representative images of the left ventricle with H&E staining. Scale bar = 50 µm. C and D Quantification of cardiomyocyte area and width in the indicated groups. E Representative images of the left ventricle with TUNEL staining, scale bar = 100 µm. F Quantification of the percentage of apoptotic cardiomyocytes (blue and pink co-stained nuclei) to total cells (pink-stained nuclei). Data are presented as mean ± SEM. Two-way ANOVA followed by Fisher’s LSD post hoc test was used to compare the effects of phenotype and treatment. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. Nppa, natriuretic peptide A; Myh7, β-myosin heavy chain; Myh6, α-myosin heavy chain