Table 1 T2D subgroups classification along with the associated clinical phenotypes. Genes were identified using the MRS and include general function.
From: Epigenomic biomarkers of cardiometabolic disease: How far are we from daily practice?
T2D subgroup | Phenotype | Genes by MRS | Gene Associations |
|---|---|---|---|
SIDD | High HbA1c | AATK, CPLX1, GRK5, LMNB2, RREB1, SOD3, SMARCA4, SYT2, TXNIP | beta-cell secretion |
SIRD | HOMA | RAB27B, RBL2 | |
MOD | High BMI, early age of onset | ELOVL2, PDGFC, SCN9A, SLC6A4, TFEB | Obesity |
MARD | Older age | CRMP1, RNF170 | Aging |