Multiple triglyceride-derived metabolic indices and incident cardiovascular outcomes in patients with type 2 diabetes and coronary heart disease

Table 4 Association between AIP and MACCEs in different subgroups

Variables	Case	AIP tertiles [HR (95% CI)]			P for trend	P for interaction
Variables	Case	T1	T2	T3	P for trend	P for interaction
Age (years)
< 65	507	1 (reference)	2.062 (1.103 ~ 3.855)	2.465 (1.342 ~ 4.526)	< 0.001	0.398
≥ 65	527	1 (reference)	1.193 (0.821 ~ 1.734)	2.876 (2.055 ~ 4.023)	< 0.001
Gender
Male	746	1 (reference)	1.132 (0.780 ~ 1.642)	2.774 (1.969 ~ 3.906)	< 0.001	0.585
Female	288	1 (reference)	1.678 (0.919 ~ 3.062)	2.418 (1.363 ~ 4.289)	0.001
BMI (kg/m²)
< 24	357	1 (reference)	0.911 (0.505 ~ 1.643)	2.525 (1.453 ~ 4.388)	0.033	0.075
≥ 24	677	1 (reference)	1.569 (1.087 ~ 2.266)	2.881 (2.052 ~ 4.045)	< 0.001
Hypertension
Yes	827	1 (reference)	1.172 (0.828 ~ 1.658)	2.751 (2.014 ~ 3.759)	< 0.001	0.504
No	207	1 (reference)	1.767 (0.873 ~ 3.574)	1.946 (0.920 ~ 4.118)	0.015
OMI
Yes	214	1 (reference)	1.009 (0.588 ~ 1.731)	2.126 (1.278 ~ 3.537)	0.006	0.365
No	820	1 (reference)	1.689 (1.148 ~ 2.483)	3.519 (2.450 ~ 5.054)	< 0.001
FCVDs
Yes	324	1 (reference)	1.261 (0.759 ~ 2.095)	2.273 (1.439 ~ 3.588)	< 0.001	0.077
No	710	1 (reference)	2.062 (1.103 ~ 3.855)	2.465 (1.342 ~ 4.526)	< 0.001

MACCEs, major adverse cardiac and cerebrovascular events; AIP, atherogenic index of plasma; BMI, body mass index; OMI, old myocardial infarction; FCVDs, familial cardiovascular diseases; T1, tertile 1; T2, tertile 2; T3, tertile 3; HR, hazard ratio; CI, confidence interval.

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