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Table 3 Effect estimates of the associations between genetic IVs for insulin (exposure) and Lp(a) (outcome) in the additional sensitivity analysis

From: Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study

Outcome

Method

nSNP

β

SE

P

Cochran Q test P

MR-Egger

Intercept (P)

MR-PRESSO

(Global P Test)

Lp(a)

IVW

12

− 0.19

0.07

0.003

0.23

 

0.26

MR-Egger

12

− 0.33

0.16

0.07

0.22

0.002 (0.38)

 

WME

12

− 0.17

0.08

0.04

   
  1. Lp(a), lipoprotein(a); IVs, instrumental variables; nSNP, number of SNP; β, MR estimate; SE, standard error; P, p-value; IVW, inverse-variance weighted method; WME, the weighted median method; MR-PRESSO, MR pleiotropy residual sum and outlier
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Cardiovascular Diabetology

ISSN: 1475-2840