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Table 1 Effect estimates of associations between fasting insulin (exposure) and Lp(a) (outcome) in conservative analysis

From: Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study

Outcome

Method

nSNP

β

SE

P

Cochran Q

test P

MR‒Egger

intercept (P)

Steiger

test P

MR-PRESSO

(Global

P test)

Lp(a)

IVW

16

− 0.15

0.05

0.003

0.53

0.001 (0.54)

5.67e−78

0.60

MR‒Egger

16

− 0.22

0.13

0.11

0.49

   

WME

16

− 0.26

0.07

0.0002

    
  1. Lp(a), lipoprotein(a); IVs, instrumental variables; nSNP, number of SNP; β, MR estimate; SE, standard error; P, p-value; IVW, inverse-variance weighted method; WME, the weighted median method; MR-PRESSO, MR pleiotropy residual sum and outlier
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Cardiovascular Diabetology

ISSN: 1475-2840