Figure 2

Cardiovascular changes after 4 weeks of treatment demonstrated beneficial effects of AC3174. (A) Systolic blood pressure. P = 0.0226 for one-way ANOVA. The pooled-over-time means of the low salt and AC3174 groups were significantly different from the high salt group (P ≤ 0.05). (B) Posterior left ventricular wall thickness. P = 0.0030 for one-way ANOVA. The pooled-over-time mean of the low salt group was significantly different from the high salt group (P ≤ 0.05). (C) Left ventricular heart mass. P = 0.0002 for one-way ANOVA. The pooled-over-time means of the low salt and AC3174 plus captopril groups were significantly different from the high salt group (P ≤ 0.05). (D) Left ventricular heart mass as a percentage of total body weight. P < 0.0001 for one-way ANOVA. The pooled-over-time means for all treatment groups, except GLP-1, were significantly different from the high salt group (P ≤ 0.05). (E) Left ventricular heart wall stress. P = 0.0512 for one-way ANOVA. The pooled-over-time means of the AC3174 and AC3174 plus captopril groups were significantly different from the high salt group (P ≤ 0.05). There were 10 rats per group at beginning of treatment. N = 3 to 10 rats per group at end of treatment actually shown. *P < 0.05 versus high salt diet alone. Mean ± SEM.